Prognostic possibilities of molecular genetic testing for assessing the risk of recurrence of papillary thyroid cancer in children

The assessment of aggressiveness and risk death in papillary thyroid cancer children is currently based on clinical criteria. To ensure a more accurate stratification, new criteria various molecular genetic markers are constantly being sought. article studied the dependence pathological manifestations level expression microRNAs presence BRAF mutation. It was found that mutation present 20.4% cases, while behavior not established. Of 14 studied, statistical differences were obtained for oncogenic miR-146b, -221, -31, oncosuppressive miR-144, which correlated with signs such as extrathyroid tumor growth, multi-focus, metastasis to neck lymph nodes.